- 2,6 diisopropyl phenol
- dervived from soybean and lecithan
- 95-99% protein bound
- elimination half life 1.5-3 hours
- eliminated in the liver by glucorinindation
- ideal agent for most healthy individuals for induction and sedation purposes
Mechanism of action:
- binds to gabaA receptors leading to increased influx of chloride ions leading to hyperpolization of the neurons.
- Chloride channel of Gaba receptor:
- side effects:
- pain on injection
- myoclonus-usually mild
- Reduced SVR due to vasodilation
- Resperatory depression, esp with use of respiratory depressant drugs, and conditions(Obstructive Sleep Apnea).
- dystonia-rare
- reduced cerebral blood flow, dec cerebral oxgen demand CRMO2, dec ICP
- Dec intraocular pressure by as much as 50%.
Prone to bacterial contamination. Throw out if drawn up in syringe after six hours.
Add comment
Comments